abstract：:Dopamine's proposed role in psychosis proved a starting point in our understanding of the neurobiology of relapse, fitting given the central role positive symptoms play. This link is reflected in early work examining neurotransmitter metabolite and drug (e.g. amphetamine, methylphenidate) challenge studies as a means ...

journal_title：Schizophrenia research

authors： Remington G,Foussias G,Agid O,Fervaha G,Takeuchi H,Hahn M

更新日期：2014-02-01 00:00:00

abstract：:Structural abnormalities in the lateral prefrontal cortex (LPFC) are well-documented in schizophrenia and recent evidence suggests that these abnormalities relate to functional outcome. Cognitive control mechanisms, reliant on the LPFC, are impaired in schizophrenia and predict functional outcome, thus impaired cognit...

journal_title：Schizophrenia research

authors： Tully LM,Lincoln SH,Liyanage-Don N,Hooker CI

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Individuals with both physical and mental health problems may have elevated levels of emergency department (ED) service utilization either for index conditions or for associated comorbidities. This study examines the use of ED services by Medicaid beneficiaries with comorbid diabetes and schizophrenia, a dyad...

journal_title：Schizophrenia research

authors： Shim RS,Druss BG,Zhang S,Kim G,Oderinde A,Shoyinka S,Rust G

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Cognitive impairment is a core feature of schizophrenia. Some evidence suggests an association between cognition deficits and gray matter reductions. In this study, we investigated the relationship between cognitive performance and gray matter volumes in patients with treatment-naïve, first-episode schizophr...

journal_title：Schizophrenia research

authors： Guo X,Li J,Wang J,Fan X,Hu M,Shen Y,Chen H,Zhao J

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Dysfunctional serotonin signaling has been linked to the pathogenesis of autism, obsessive compulsive disorder, mood disorders and schizophrenia. While the hypo-activity of serotonin signaling is involved in the pathogenesis of depression, anxiety and obsessive compulsive disorder; LSD, an agonist of serot...

journal_title：Schizophrenia research

authors： Abdolmaleky HM,Nohesara S,Ghadirivasfi M,Lambert AW,Ahmadkhaniha H,Ozturk S,Wong CK,Shafa R,Mostafavi A,Thiagalingam S

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:International studies indicate that the median prevalence of psychotic experiences in children is 7%. It has been proposed that environmental stress during pregnancy may affect the neurodevelopment of the foetus and lead to a vulnerability in the child to later stressors and psychopathology. AIM:In this stu...

journal_title：Schizophrenia research

authors： Dorrington S,Zammit S,Asher L,Evans J,Heron J,Lewis G

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Neurodevelopmental models of schizophrenia suggest that cognitive deficits may be observed during childhood and adolescence, long before the onset of psychotic symptoms. Elucidating the trajectory of normal cognitive development during childhood and adolescence may therefore provide a basis for identifying s...

journal_title：Schizophrenia research

authors： Nitzburg GC,Derosse P,Burdick KE,Peters BD,Gopin CB,Malhotra AK

更新日期：2014-01-01 00:00:00

abstract：:In this study we use high resolution Magnetic Resonance imaging (MRI) and apply rigorous manual tracing criteria in order to assess volumetrically the prefrontal cortex (PFC) in schizophrenia. Previous MRI studies suggested PFC is included in neural systems necessary for emotional processing and cognition, and regiona...

journal_title：Schizophrenia research

authors： Ohtani T,Levitt JJ,Nestor PG,Kawashima T,Asami T,Shenton ME,Niznikiewicz M,McCarley RW

更新日期：2014-01-01 00:00:00

abstract：:CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether CACNA1C is a risk gene for schizoph...

journal_title：Schizophrenia research

authors： Zheng F,Zhang Y,Xie W,Li W,Jin C,Mi W,Wang F,Ma W,Ma C,Yang Y,Du B,Li K,Liu C,Wang L,Lu T,Zhang H,Wang Y,Lu L,Lv L,Zhang D,Yue W

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Randomized trials targeting cannabis use disorders in patients with psychosis have generally been unsuccessful. One of the largest such trials was the CapOpus trial, which had an impact on the number of monthly joints used, but not on the number of days with cannabis use or positive or negative symptoms. OB...

journal_title：Schizophrenia research

authors： Hjorthøj CR,Orlovska S,Fohlmann A,Nordentoft M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Advanced paternal age (APA) is associated with increased risk for schizophrenia, but its effect on treatment response has not been longitudinally studied. METHODS:Association of parental ages at the time of the child's birth with age of onset, initial symptom severity and treatment response (to placebo and ...

journal_title：Schizophrenia research

authors： Opler M,Malaspina D,Gopal S,Nuamah I,Savitz AJ,Singh J,Hough D

更新日期：2013-12-01 00:00:00

abstract：:Research has demonstrated that individuals with schizophrenia fail to appropriately use negative feedback to guide learning. These learning deficits are thought to arise from abnormalities in midbrain dopamine activity. Primary and enduring negative symptoms are also associated with abnormal dopamine activity and are ...

journal_title：Schizophrenia research

authors： Vogel SJ,Strauss GP,Allen DN

更新日期：2013-12-01 00:00:00

abstract：:Pro-inflammatory cytokines have been consistently reported to be elevated in schizophrenia patients. However, it is not known whether cytokines influence the presentation of psychotic symptoms. To address this issue, we evaluated the relationship between levels of inflammatory molecules and psychopathological paramete...

journal_title：Schizophrenia research

authors： Dimitrov DH,Lee S,Yantis J,Valdez C,Paredes RM,Braida N,Velligan D,Walss-Bass C

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:Progressive atrophy occurs in brain regions involved in the working memory network along the schizophrenia's course, but without parallel evolution of working memory impairment. We investigated the functional organization inside this network at different stages of the disease. METHODS:Twenty-eight patient...

journal_title：Schizophrenia research

authors： Faget-Agius C,Boyer L,Lançon C,Richieri R,Fassio E,Soulier E,Chanoine V,Auquier P,Ranjeva JP,Guye M

更新日期：2013-12-01 00:00:00

abstract：:The aim of this study is to compare the neurocognitive functions in individuals with clinical or genetic risk for psychosis, in patients with first-episode schizophrenia (FES) and in healthy controls. We compared cognitive functions of 52 individuals at ultra high risk (UHR) for psychosis, 53 patients with FES, their ...

journal_title：Schizophrenia research

authors： Üçok A,Direk N,Koyuncu A,Keskin-Ergen Y,Yüksel Ç,Güler J,Karadayı G,Akturan E,Devrim-Üçok M

更新日期：2013-12-01 00:00:00

abstract：:There has been increasing interest in studying the impact of physical activity on the psychological and physical well-being and functioning in patients with first-episode psychosis. The exploration of factors which contribute to physical activity in psychosis may open up opportunities for improvement of functional out...

journal_title：Schizophrenia research

authors： Lee EH,Hui CL,Chang WC,Chan SK,Li YK,Lee JT,Lin JJ,Chen EY

更新日期：2013-11-01 00:00:00

abstract：:Cognitive deficits have been recognized as a core feature of schizophrenia (SZ) and are present in most patients. Verbal memory (VM), working memory (WM), and executive function (EF) are domains commonly impaired in patients with SZ. These latter domains have been related to the genetic risk of the disorder characteri...

journal_title：Schizophrenia research

authors： Massuda R,Bücker J,Czepielewski LS,Narvaez JC,Pedrini M,Santos BT,Teixeira AS,Souza AL,Vasconcelos-Moreno MP,Vianna-Sulzbach M,Goi PD,Belmonte-de-Abreu P,Gama CS

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:The study was to examine the levels of adiponectin (APN) and other cytokines, and body metabolism in drug naïve, first episode schizophrenia patients with normal weight. METHODS:Ninety-six drug naïve, first episode schizophrenia patients with normal weight (SZ group), 60 healthy individuals with normal weigh...

journal_title：Schizophrenia research

authors： Song X,Fan X,Song X,Zhang J,Zhang W,Li X,Gao J,Harrington A,Ziedonis D,Lv L

更新日期：2013-10-01 00:00:00

abstract：:Executive functioning (EF) impairments are common in schizophrenia. There are two propositions regarding the causes of these impairments: (1) executive impairments are the result of the compounding effects of deficits in lower order cognitive skills (e.g. processing speed, attention) or (2) EF impairments exist in the...

journal_title：Schizophrenia research

authors： Neill E,Rossell SL

更新日期：2013-10-01 00:00:00

abstract：:The influence of neurocognition, including general intelligence, on theory of mind (ToM) among patients with schizophrenia spectrum disorder is controversial. The purpose of the present study was to identify the influences of the non-ToM cognition and general intelligence on ToM performance in individuals at ultra-hig...

journal_title：Schizophrenia research

authors： Hur JW,Byun MS,Shin NY,Shin YS,Kim SN,Jang JH,Kwon JS

更新日期：2013-09-01 00:00:00

abstract：:Diminished expression is a diagnostic feature of a range of schizophrenia-spectrum disorders/conditions and is often unresponsive to treatment, is present across premorbid, first episode and various clinical states, and is considered a poor prognostic indicator. Surprisingly, little is known about diminished expressio...

journal_title：Schizophrenia research

authors： Cohen AS,Morrison SC,Callaway DA

更新日期：2013-08-01 00:00:00

abstract：:Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-...

journal_title：Schizophrenia research

authors： Sheng J,Zhu Y,Lu Z,Liu N,Huang N,Zhang Z,Tan L,Li C,Yu X

更新日期：2013-08-01 00:00:00

abstract：:Sustained attention deficits and high rates of smoking are often observed in patients with schizophrenia. This has led to the hypothesis that patients may smoke as an attempt to ameliorate cognitive deficits related to abnormal nicotinic structure and function. Continuous performance tasks (CPT) are often used to inde...

journal_title：Schizophrenia research

authors： Roth M,Hong LE,McMahon RP,Fuller RL

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:In many natural audiovisual events (e.g., the sight of a face articulating the syllable /ba/), the visual signal precedes the sound and thus allows observers to predict the onset and the content of the sound. In healthy adults, the N1 component of the event-related brain potential (ERP), reflecting neural ac...

journal_title：Schizophrenia research

authors： Stekelenburg JJ,Maes JP,Van Gool AR,Sitskoorn M,Vroomen J

更新日期：2013-07-01 00:00:00

abstract：:Cannabis use is highly prevalent worldwide and it is associated with psychosis, but its effects on brain structure and cognition are still controversial. The aim of this paper is to investigate cognitive functioning and brain structure in patients with their first episode of psychosis who used Cannabis. We examined gr...

journal_title：Schizophrenia research

authors： Cunha PJ,Rosa PG,Ayres Ade M,Duran FL,Santos LC,Scazufca M,Menezes PR,dos Santos B,Murray RM,Crippa JA,Busatto GF,Schaufelberger MS

更新日期：2013-07-01 00:00:00

abstract：:Patients with schizophrenia demonstrate a generalized deficit across multiple cognitive domains. However, it is unknown whether this deficit is largely due to lower intelligence, or if there is an impact of schizophrenia which cannot be accounted for by measures of general intellectual ability (GIA). We created four I...

journal_title：Schizophrenia research

authors： Gray BE,McMahon RP,Gold JM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Many patients with schizophrenia suffer from metabolic symptoms and weight gain in which predispose them to obesity, diabetes, and cardiovascular problems. This trial examines the efficacy and safety of zonisamide on weight and body mass index in patients with schizophrenia being administered with atypical a...

journal_title：Schizophrenia research

authors： Ghanizadeh A,Nikseresht MS,Sahraian A

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:We recently reported that the type-2 cytokine response is increased in schizophrenia. The aim of this study was to analyse the effects of antipsychotic drugs on the serum levels of type-1 (TNF-α, IFN-γ), type-2 (IL-4, IL-10), type-17 (IL-17) and regulatory cytokines (TGF-β, IL-27 and IL-6). METHODS:Cytokine ...

journal_title：Schizophrenia research

authors： Borovcanin M,Jovanovic I,Radosavljevic G,Djukic Dejanovic S,Stefanovic V,Arsenijevic N,Lukic ML

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Mismatch negativity (MNN) and P3a are event related potential (ERP) measures of early sensory information processing. These components are usually conceptualized as being "pre-attentive" and therefore immune to changes with variations in attentional functioning. This study aimed to determine whether manipula...

journal_title：Schizophrenia research

authors： Rissling AJ,Park SH,Young JW,Rissling MB,Sugar CA,Sprock J,Mathias DJ,Pela M,Sharp RF,Braff DL,Light GA

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:To develop a pharmacokinetic-pharmacodynamic (PK-PD) model using individual-level data of Positive and Negative Syndrome Scale (PANSS) total score to characterize the antipsychotic drug effect taking into account the placebo effect and dropout rate. In addition, a clinical utility (CU) criterion that describ...

journal_title：Schizophrenia research

authors： Pilla Reddy V,Kozielska M,Suleiman AA,Johnson M,Vermeulen A,Liu J,de Greef R,Groothuis GM,Danhof M,Proost JH

更新日期：2013-05-01 00:00:00

abstract：:Our aim was to investigate the association between parental psychosis and potential risk factors for schizophrenia and their interaction. We evaluated whether the factors during pregnancy and birth have a different effect among subjects with and without a history of parental psychosis and whether parental psychosis ma...

journal_title：Schizophrenia research

authors： Keskinen E,Miettunen J,Koivumaa-Honkanen H,Mäki P,Isohanni M,Jääskeläinen E

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:Examine the association between sedentary behavior and psychiatric symptoms among overweight and obese adults with schizophrenia or schizoaffective disorders (SZO/SA). DESIGN:Randomized clinical trial; Weight Assessment and Intervention in Schizophrenia Treatment (WAIST) Study: baseline data collected 2005-2...

journal_title：Schizophrenia research

authors： Janney CA,Ganguli R,Richardson CR,Holleman RG,Tang G,Cauley JA,Kriska AM

更新日期：2013-04-01 00:00:00

abstract：:Glutamate transporters facilitate the buffering, clearance and cycling of glutamate and play an important role in maintaining synaptic and extrasynaptic glutamate levels. Alterations in glutamate transporter expression may lead to abnormal glutamate neurotransmission contributing to the pathophysiology of schizophreni...

journal_title：Schizophrenia research

authors： Shan D,Lucas EK,Drummond JB,Haroutunian V,Meador-Woodruff JH,McCullumsmith RE

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophr...

journal_title：Schizophrenia research

authors： Demeter E,Guthrie SK,Taylor SF,Sarter M,Lustig C

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Second-generation antipsychotics (SGAs) increase the risk of type 2 diabetes. The mechanism is thought to center on drug-induced weight gain, which starts the dysmetabolic cascade of insulin resistance, increased insulin production and pancreatic beta-cell failure. An independent effect of SGAs on insulin se...

journal_title：Schizophrenia research

authors： Manu P,Correll CU,Wampers M,van Winkel R,Yu W,Shiffeldrim D,Kane JM,De Hert M

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:To (a) compare the size of the dorsal and ventral striatum (caudate and putamen) in a large sample of antipsychotic-naïve individuals with schizotypal personality disorder (SPD) and healthy control participants; (b) examine symptom correlates of striatal size in SPD. METHODS:The left and right caudate and pu...

journal_title：Schizophrenia research

authors： Chemerinski E,Byne W,Kolaitis JC,Glanton CF,Canfield EL,Newmark RE,Haznedar MM,Novakovic V,Chu KW,Siever LJ,Hazlett EA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Alterations in bone mineral density (BMD) in patients with psychotic disorder may reflect the effect of treatment (disease effect observed in patients but not their siblings) or, as an intermediate marker of cumulative endogenous estrogen exposure, alterations in the neuroprotective effect of estrogen in the...

journal_title：Schizophrenia research

authors： van der Leeuw C,Habets P,Domen P,van Kroonenburgh M,van Os J,Marcelis M,for G.R.O.U.P.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Heterogeneity in clinical outcomes may be caused by factors working at multiple levels, e.g., between groups, between subjects, or within subjects over time. A more nuanced assessment of differences in variation among schizophrenia patients and between patients and healthy comparison subjects can clarify eti...

journal_title：Schizophrenia research

authors： Thompson WK,Savla GN,Vahia IV,Depp CA,O'Hara R,Jeste DV,Palmer BW

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Patients with psychotic disorders show impairments in the recognition of emotions in other people. These impairments have been associated with poor social functioning as measured by self-report questionnaires, clinical interviews and laboratory-based tests of social skills. The ecological validity of these t...

journal_title：Schizophrenia research

authors： Janssens M,Lataster T,Simons CJ,Oorschot M,Lardinois M,van Os J,Myin-Germeys I,GROUP.

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Aprosody, or flattened speech intonation, is a recognized negative symptom of schizophrenia, though it has rarely been studied from a linguistic/phonological perspective. To bring the latest advances in computational linguistics to the phenomenology of schizophrenia and related psychotic disorders, a clinica...

journal_title：Schizophrenia research

authors： Covington MA,Lunden SL,Cristofaro SL,Wan CR,Bailey CT,Broussard B,Fogarty R,Johnson S,Zhang S,Compton MT

更新日期：2012-12-01 00:00:00